Domain swapping in G-protein coupled receptor dimers
نویسندگان
چکیده
منابع مشابه
Domain swapping in G-protein coupled receptor dimers.
Computer simulations were performed on models of the beta2-adrenergic receptor dimer, including 5,6-domain swapped dimers which have been proposed as the active, high affinity form (here the dimer interface lies between helices 5 and 6). The calculations suggest that the domain swapped dimer is a high energy structure in both the apo dimer and in the presence of propranolol. In the presence of ...
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A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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G protein-coupled receptors (GPCRs) are ubiquitous and essential in modulating virtually all physiological processes. These receptors share a similar structural design consisting of the seven-transmembrane alpha-helical segments. The active conformations of the receptors are stabilized by an agonist and couple to structurally highly conserved heterotrimeric G proteins. One of the most important...
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Zingg, 11. H., Rozen, F., Breton, C., Larcher, A., Neculcea, J., Chu, K., Russo, C. and Arslan, A. (1995) Adv. Exp. Med. Biol. 395, 395-404 Bale, T. L., Pedersen, C. A. and Dorsa, D. M. (1995) Adv. Exp. Med. Biol. 395, 269-280 Ostrowski, N. L. and Lolait, S. J. (1995) Adv. Exp. Med. Biol. 395, 329-340 Flint, A. P. F., Lamming, G. E., Stewart, H. J. and Abayasekara, D. R. E. (1994) Philos. Trans...
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There has been much speculation regarding the functional relevance of G protein-coupled receptor heterodimers, primarily because demonstrating their existence in vivo has proven to be a considerable challenge. Here we show that the opioid agonist ligand 6'-guanidinonaltrindole (6'-GNTI) has the unique property of selectively activating only opioid receptor heterodimers but not homomers. Importa...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 1998
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/11.12.1181